SYNTHESIS OF MONO AND BİS Α-KETOACIDIC ESTERS AND STUDY OF THEIR ANTIMICROBIAL PROPERTIES

Summary: Recently, our scientific group has been studying in detail the synthesis and structural properties of dichlorodiazadienes obtained from the interaction of N-substituted hydrazones of benzoyl and terephthalaldehyde with polyhalogen methanes in the presence of a CuCl catalyst. This class of compounds, in addition to their application as azo dyes, can be used as important synthons in the synthesis of other organic compounds. Various research works have been carried out in this area. Mainly, their reactions with nucleophiles have been widely studied. Taking all this into account, we have studied the solvolysis reactions of mono and bis dichlorodiazadienes and synthesized the corresponding compounds.Four novel compounds were synthesized and their antimicrobial activities were evaluated using agar well diffusion method. The results revealed that fungal strains were more sensitive to all compounds compared to bacteria. Pseudomonas aeruginosa was the most sensitive gram-negative bacterium to compound III (Methyl (Z)-2-(2-(4-chlorophenyl) hydrazineylidene)-2-phenylacetate) with 20.0 mm as the diameter of inhibition zone. Escherichia coli and Bacillus mesentericus were highly resistant to compounds I. Candida albicans was the most susceptible fungal strain to compound IV ((E)-1-(4-chlorophenyl)-2-(2,2-dichloro-1-phenylvinyl) diazene) with an inhibition zone of 24.0 mm.