THE ANTIFUNGAL PROPERTIES OF 1,2,3-TRİAZOLES

Summary: Fungicides are very important for agriculture, animal husbandry and medicine, as the various infections induced by certain fungi cause harm to plants and animals which are used as a source of food, as well as directly to humans themselves. More than 1,5 million deaths are caused by fungi each year, both the incidence of fungal infections and the resistance against already existing antifungal drugs are on the rise, which renders the search for inexpensive and new effective fungicides very urgent. On the other hand, some compounds containing 1,2,3-triazole moieties (for example, Radezolid and Cefatrizine) display strong antifungal activity and are used as fungicides. Azoles prevent lanosterol 14-alpha-demethylase enzyme from converting to ergosterol, and therefore inhibit growth of fungi. Today many scientists all across the world synthesize new compounds containing 1,2,3-triazole moieties and research their antifungal properties by applying them against various pathogenic fungal strains. This article is a review of recent scientific literature describing antifungal activity of compounds containing 1,2,3-triazole moieties.